News Bureau

A cholesterol byproduct facilitates breast cancer’s spread by hijacking immune cells, a new University of Illinois study found.

The Carle Illinois College of Medicine, the first engineering-based medical school, has received preliminary acreditation from the Liaison Committee on Medical Education and is recruiting students for its first class.

Sharon M. Donovan, a professor of nutrition and the Melissa M. Noel Endowed Chair in Nutrition and Health at the University of Illinois, was elected today (Oct. 16) to the National Academy of Medicine.

Stemlike cells at the edge of melanoma tumors secrete factors to promote blood-vessel growth, allowing the cancer to grow and spread.

Stem cells taken from muscle tissue could promote better blood flow in patients with diabetes who develop peripheral artery disease, a painful complication that can require surgery or lead to amputation.

Encouraging children to drink water with their school lunches could prevent more than half a million cases of child obesity and overweight -- and trim the medical and societal costs by more than $13 billion, a new study suggests.

A newly funded U. of I. initiative is expanding the number of behavioral health providers available to care for residents in medically underserved and rural communities.

A new shape-shifting polymer can target and kill Helicobacter pylori bacteria in the stomach without killing helpful bacteria in the gut.

Specially tailored, ultrafast pulses of light can trigger neurons to fire and could one day help patients with light-sensitive circadian or mood problems, according to a new study in mice at the University of Illinois.

Centuries of study have yielded many theories about how the brain gives rise to human intelligence. A new theory makes the case that the brain’s dynamic properties – how it is wired but also how that wiring shifts in response to changing intellectual demands – are the best predictors of intelligence in the human brain.

A drug that spurs cancer cells to self-destruct has been cleared for use in a clinical trial of patients with anaplastic astrocytoma, a rare malignant brain tumor, and glioblastoma multiforme, an aggressive late-stage cancer of the brain. This phase Ib trial will determine if the experimental drug PAC-1 can be used safely in combination with a standard brain-cancer chemotherapy drug, temozolomide.

Researchers are sending tiny drug-laden nanoparticles on a mission to seek and destroy cancer stem cells.

Two studies – one in mice and the other in human subjects – offer the first definitive evidence that exercise alone can change the composition of microbes in the gut. The studies were designed to isolate exercise-induced changes from other factors – such as diet or antibiotic use – that might alter the intestinal microbiota.

Researchers have developed a way to find hypoxia, or low oxygen in tissue, noninvasively in real time with light and ultrasound.

People who consume 18 grams of protein from whole eggs or from egg whites after engaging in resistance exercise differ dramatically in how their muscles build protein, a process called protein synthesis, during the post-workout period, researchers report in a new study. Specifically, the post-workout muscle-building response in those eating whole eggs is 40 percent greater than in those consuming an equivalent amount of protein from egg whites, the team found.

Treating ovariectomized mice with a combination of conjugated estrogens and the drug bazedoxifene triggers the expression of genes that improve metabolism and prevent weight gain – without stimulating the uterus and increasing risks of reproductive cancer, a new study at the University of Illinois suggests.

Preterm babies born early in the third trimester of pregnancy are likely to experience delays in the development of the auditory cortex, a brain region essential to hearing and understanding sound, a new study reveals. Such delays are associated with speech and language impairments at age 2, the researchers found.

Third-graders who spend a class session in a natural outdoor setting are more engaged and less distracted in their regular classroom afterward than when they remain indoors, scientists found in a new study.

A drug-carrying microsphere within a cell-bearing microcapsule could be the key to transplanting insulin-secreting pig pancreas cells into human patients whose own cells have been destroyed by type I diabetes.

A new study of middle-aged women found that sleep problems vary across the stages of menopause, yet are consistently correlated with hot flashes and depression.

Iron deficiency in the first four weeks of a piglet’s life – equivalent to roughly four months in a human infant – impairs the development of key brain structures, scientists report. The abnormalities remain even after weeks of iron supplementation begun later in life, the researchers found.

A new study links doing one’s homework, being interested and behaving responsibly in high school to better academic and career success as many as 50 years later. This effect, reported in the Journal of Personality and Social Psychology, holds true even after accounting for parental income, IQ and other factors known to influence achievement, researchers report.

Researchers say they can now produce a vast library of unique cyclic compounds, some with the capacity to interrupt specific protein-protein interactions that play a role in disease. The new compounds have cyclic structures that give them stability and enhance their ability to bind to their targets.  

By peering at the brains of study subjects prompted to suppress negative emotions, scientists have gained new insights into how emotional regulation influences negative feelings and memories. They hope the findings will lead to new methods to combat depression.

Latinos who are the most optimistic are more likely to have healthy hearts, according to a new study of more than 4,900 Latinos in the U.S. led by University of Illinois social work professor Rosalba Hernandez.

Federal funding is needed to improve diagnosis and treatment of perinatal depression in Latina and black women, according to University of Illinois kinesiology and community health professor Sandraluz Lara-Cinisomo. 

Cancer lurking in tissue could be more easily found when looking through a butterfly’s eye.

Consuming high amounts of carbohydrates and various forms of sugar during the year prior to treatment for head and neck cancer may increase patients’ risks of cancer recurrence and mortality, a new study reports.

Losing an arm doesn’t have to mean losing all sense of touch, thanks to prosthetic arms that stimulate nerves with mild electrical feedback. University of Illinois researchers have developed a control algorithm that regulates the current so a prosthetics user feels steady sensation, even when the electrodes begin to peel off or when sweat builds up. 

Workplace violence is an endemic problem for front-line health care workers in Illinois, says new research from U. of I. labor and employment relations professor Emily E. LB. Twarog.

Brazilians with less education are more likely to self-report as being in poor health, according to a study using data from nationwide surveys distributed every five years from 1998 to 2013. The study also found that general subjective health did not improve over the study period, even though more people gained education throughout the study, indicating that other factors associated with poor education may need to be addressed to improve self-perceptions of health.

University of Illinois researchers say they now know how to track and map drug and gene delivery vehicles to evaluate which are most effective at infiltrating cells and getting to their targets, insight that could guide development of new pharmaceutical agents. The researchers described their tracking system and their findings on the most effective delivery vehicles in the journal Nature Communications. 

University of Illinois engineers built a 3-D printer that offers a sweet solution to making detailed structures that commercial 3-D printers can’t: Rather than a layer-upon-layer solid shell, it produces a delicate network of thin ribbons of hardened isomalt, the type of sugar alcohol used to make throat lozenges.

The water-soluble, biodegradable glassy sugar structures have multiple applications in biomedical engineering, cancer research and device manufacturing.

Women in the Champaign-Urbana area who experience perinatal depression and their health care providers will meet with an international group of experts June 1-2 in Champaign for a workshop about new methods of detecting and treating the mood disorder.

Researchers report in a new study that the bacterium Helicobacter pylori – a major contributor to gastritis, ulcers and stomach cancer – resists the body’s immune defenses by shutting down energy production within the cells of the stomach lining that serve as a barrier to infection.

Neighborhood characteristics are associated with late-stage diagnoses and higher mortality rates among urban African-American women, a new study shows.

Long-term therapy with estrogen and bazedoxifene changes the microbial composition and activity in the gut, affecting how estrogen is metabolized, University of Illinois researchers found in a new mouse study.

A new microscope system can image living tissue in real time and in molecular detail, without any chemicals or dyes, report researchers at the University of Illinois.

A new synthetic enzyme, crafted from DNA rather than protein, flips lipid molecules within the cell membrane, triggering a signal pathway that could be harnessed to induce cell death in cancer cells. It is the first such synthetic enzyme to outperform its natural counterparts.

Editor’s note: The number of tick-borne illnesses diagnosed annually in the United States doubled between 2004 and 2016, according to a recent report from the Centers for Disease Control and Prevention. Summer is prime tick season, and people spending time outdoors should be vigilant, says University of Illinois entomology professor Brian F. Allan. An expert in the spread of insect- and tick-borne diseases, Allan discussed ticks in Illinois, how to prevent bites and when to seek medical attention in an interview with News Bureau biomedical sciences editor Liz Ahlberg Touchstone.

A class of molecules formed when the body metabolizes omega-3 fatty acids could inhibit cancer’s growth and spread, University of Illinois researchers report in a new study in mice.

Male and female rats exposed in the womb and during lactation to plasticizing chemicals known as phthalates had significantly fewer neurons and synapses than those that were not exposed, researchers report in a new study. The phthalate-exposed rats had reductions in the size of their medial prefrontal cortex, a brain region that regulates behavior, and showed deficits in cognitive flexibility.  

In one of the largest studies of its kind, researchers analyzed chikungunya and dengue outbreak data from 76 countries over a period of 50 years, focusing on regions across the Indian Ocean that are hard hit by these and other mosquito-borne infectious diseases.

After a primary tumor is treated, cancer stem cells may still lurk in the body, ready to metastasize and cause a recurrence of the cancer in a form that’s more aggressive and resistant to treatment. University of Illinois researchers have developed a molecular probe that seeks out these elusive cells and lights them up so they can be identified, tracked and studied not only in cell cultures, but in their native environment: the body.

In a paper published in the journal ACS Central Science, the researchers described the probe’s effectiveness in identifying cancer stem cells in cultures of multiple human cancer cell lines as well as in live mice.

In a new study in cells, University of Illinois researchers have adapted CRISPR gene-editing technology to cause the cell’s internal machinery to skip over a small portion of a gene when transcribing it into a template for protein building. This gives researchers a way not only to eliminate a mutated gene sequence, but to influence how the gene is expressed and regulated.

Such targeted editing could one day be useful for treating genetic diseases caused by mutations in the genome, such as Duchenne’s muscular dystrophy, Huntington’s disease or some cancers.

Illinois professor Ruby Mendenhall is focused on issues of poverty, inequality and violence, but crosses many academic boundaries in search of answers.

A new point-of-care rapid-sensing device can detect a key marker of eye injury in minutes – a time frame crucial to treating eye trauma.  

University of Illinois researchers developed a gel laden with gold nanoparticles that changes color when it reacts with a teardrop containing ascorbic acid, released from a wound to the eye. In a new study published in the journal Biosensors and Bioelectronics, the researchers used the sensor, called OjoGel, to measure ascorbic acid levels in artificial tears and in clinical samples of fluid from patients’ eyes. 

A new study reveals a previously unknown mechanism that governs whether viruses that infect bacteria will quickly kill their hosts or remain latent inside the cell. The discovery, reported in the journal eLife, also may apply to viruses that infect humans and other animals, the researcher said.

A geologist, a microscopist and a doctor walk into a lab and, with their colleagues from across the nation, make a discovery that overturns centuries of thought about the nature and composition of kidney stones. The team’s key insight, reported in the journal Scientific Reports, is that kidney stones are built up in calcium-rich layers that resemble other mineralizations in nature, such as those forming coral reefs or arising in hot springs, Roman aqueducts or subsurface oil fields.

In Greek mythology, Zeus punishes the trickster Prometheus by chaining him to a rock and sending an eagle to eat a portion of his liver every day, in perpetuity. It was the right organ to target – the liver has the ability to regenerate itself, though not overnight nor for eternity.

New research conducted by biochemists at the University of Illinois has determined how damaged liver cells repair and restore themselves through a signal to return to an early stage of postnatal organ development.