News Bureau

Researchers have demonstrated that a small molecule can transport iron in human cells and live animals when proteins that normally do the same job are missing, a condition that often causes severe anemia in patients. Such “molecular prosthetics” might treat a host of incurable diseases caused by protein deficiencies, such as anemias, cystic fibrosis or certain types of heart disease.

CHAMPAIGN, Ill. - A new approach to outwit resistance to antibiotics has been discovered by a team of researchers at the University of Illinois at Urbana-Champaign.

When tested in brain cells and in a mouse model of Alzheimer’s disease, a new compound significantly reduced the number of amyloid plaques in the brain, lessened brain inflammation and diminished other molecular markers of the disease.

A new study found that 24-month-old children who spent less than 60 minutes looking at screens each day and those who engaged in daily physical activity had better executive function than their peers. Executive function includes the ability to remember, plan, pay attention, shift between tasks and regulate one's thoughts and behavior.

A 10-week muscle-building and dietary program involving 50 middle-aged adults found no evidence that eating a high-protein diet increased strength or muscle mass more than consuming a moderate amount of protein while training. The intervention involved a standard strength-training protocol with sessions three times per week. None of the participants had previous weightlifting experience.

Studies indicate that homemade masks help combat the spread of viruses like COVID-19 when combined with frequent hand-washing and physical distancing. Many of these studies focus on the transfer of tiny aerosol particles; however, researchers say that speaking, coughing and sneezing generates larger droplets that carry virus particles. Because of this, mechanical engineer Taher Saif said the established knowledge may not be enough to determine how the effectiveness of some fabrics used in homemade masks.

CHAMPAIGN, Ill. - The infant mortality rate set forth as a national goal in the federal government's Healthy People 2020 initiative is likely to be attained by only one demographic group - highly educated white mothers, the authors of a new study say.

A study of the West Nile virus risk associated with “dry” water-detention basins in central Illinois took an unexpected turn when land managers started mowing the basins. The mowing of wetland plants in basins that failed to drain properly led to a boom in populations of Culex pipiens mosquitoes, which can carry and transmit the deadly virus, researchers report.

RNA transcribed from genes that seem not to code for anything may play an important role in regulating cancer, a new study suggests.

A number of these noncoding RNA fragments lie next to known cancer genes, the study found. Understanding how they interact with those cancer genes could open new avenues to understanding cancer’s behavior and treating it.

A new study demonstrates that nanopores can be used to identify all 20 amino acids in proteins, a major step toward protein sequencing.

Detecting cancer early, just as changes are beginning in DNA, could enhance diagnosis and treatment as well as further our understanding of the disease. A new study by University of Illinois researchers describes a method to detect, count and map tiny additions to DNA called methylations, which can be a warning sign of cancer, with unprecedented resolution.

In regenerative medicine, an ideal treatment for patients whose muscles are damaged from lack of oxygen would be to invigorate them with an injection of their own stem cells.

In a new study published in the journal ACS Nano, researchers at the University of Illinois at Urbana-Champaign demonstrated that “nanostimulators” – nanoparticles seeded with a molecule the body naturally produces to prompt stem cells to heal wounds – can amp up stem cells’ regenerative powers in a targeted limb in mice.

Exercise prompts muscles to release molecular cargo that boosts brain cell function and connection, but the process is not well understood. New research from the University of Illinois Urbana-Champaign found that the nerves that tell muscles to move also prompt them to release more of the brain-boosting factors.

Iron deficiency in the first four weeks of a piglet’s life – equivalent to roughly four months in a human infant – impairs the development of key brain structures, scientists report. The abnormalities remain even after weeks of iron supplementation begun later in life, the researchers found.

CHAMPAIGN, Ill. - A recent study by University of Illinois professor of psychology Dolores Albarracín and her colleagues at the University of Florida and the Alachua County Health Department in Florida found a method to increase enrollment among high-risk individuals in HIV prevention programs.

A new antifungal molecule, devised by tweaking the structure of prominent antifungal drug Amphotericin B, has the potential to harness the drug’s power against fungal infections while doing away with its toxicity, researchers at the University of Illinois Urbana-Champaign and collaborators at the University of Wisconsin-Madison report in the journal Nature.

CHAMPAIGN, Ill. — New compounds that specifically attack fungal infections without attacking human cells could transform treatment for such infections and point the way to targeted medicines that evade antibiotic resistance.

Scientists have developed a promising new method to combat the age-related losses in muscle mass that often accompany immobility after injury or illness. Their technique, demonstrated in mice, arrests the process by which muscles begin to deteriorate at the onset of exercise after a period of inactivity.

A new approach to treating breast cancer kills 95-100% of cancer cells in mouse models of human estrogen-receptor-positive breast cancers and their metastases in bone, brain, liver and lungs. The newly developed drug, called ErSO, quickly shrinks even large tumors to undetectable levels.

Cancer lurking in tissue could be more easily found when looking through a butterfly’s eye.

CHAMPAIGN, lll. - For cancer drug developers, finding an agent that kills tumor cells is only part of the equation. The drug must also spare healthy cells. And - ideally - its effects will be reversible, to cut short any potentially dangerous side effects.

CHAMPAIGN, lll. - Researchers have discovered a new compound that restores the health of mice infected with methicillin-resistant Staphylococcus aureus (MRSA), an otherwise dangerous bacterial infection. The new compound targets an enzyme not found in human cells but which is essential to bacterial survival.

Scientists have developed new drug compounds that thwart the pro-cancer activity of FOXM1, a transcription factor that regulates the activity of dozens of genes. The new compounds suppress tumor growth in human cells and in mouse models of several types of human breast cancer.

CHAMPAIGN, Ill. - Research by scientists based at the University of Illinois at Urbana-Champaign may lead to the development of a new breed of "multimodal" contrast agents that could work within a host of medical imaging platforms - from ultrasound and computed tomography (CT) to magnetic resonance imaging and molecular imaging.

A new CRISPR gene-editing method can inactivate one of the genes responsible for an inherited form of ALS, scientists at the University of Illinois at Urbana-Champaign report in a new study. The novel treatment slowed disease progression, improved muscle function and extended lifespan in mice with an aggressive form of ALS.

In a new study in cells, University of Illinois researchers have adapted CRISPR gene-editing technology to cause the cell’s internal machinery to skip over a small portion of a gene when transcribing it into a template for protein building. This gives researchers a way not only to eliminate a mutated gene sequence, but to influence how the gene is expressed and regulated.

Such targeted editing could one day be useful for treating genetic diseases caused by mutations in the genome, such as Duchenne’s muscular dystrophy, Huntington’s disease or some cancers.

A new compound that targets a receptor within sarcoma cancer cells shrank tumors and hampered their ability to spread in mice and pigs, a study from researchers at the University of Illinois reports.

CHAMPAIGN, Ill. - In his 2014 State of the Union address, President Barack Obama referred to an August 2013 Centers for Disease Control and Prevention study that showed a decline in the obesity rate among low-income preschool children, saying, "Michelle's Let's Move! partnership with schools, businesses and local leaders has helped bring down childhood obesity rates for the first time in 30 years, and that's an achievement that will improve lives and reduce health care costs for decades to come."

Whether the need is to educate people in West Africa about preventing Ebola or to train farmers in Latin America on preventing postharvest loss, Scientific Animations without Borders has an app – and an animated video – for that.

Lung cancer can be elusive to spot and difficult to treat, but University of Illinois Urbana-Champaign researchers have developed a finely tuned molecular agent that can precisely target lung and other cancer cells for imaging and treatment.

A new set of molecular building blocks aims to make complex chemistry as simple and accessible as a toy construction kit. Researchers at the University of Illinois Urbana-Champaign developed a new class of chemical building blocks that simply snap together to form 3D molecules with complex twists and turns, and an automated machine to assemble the blocks like a 3D printer for molecules. This automation could allow chemists and nonchemists alike to develop new pharmaceuticals, materials, diagnostic probes, catalysts, perfumes, sweeteners and more.

A multidisciplinary team of researchers at the University of Illinois at Urbana-Champaign has developed tiny sensors that measure oxygen transport in bovine lung tissue. The study – which establishes a new framework for observing the elusive connection between lung membranes, oxygen flow and related disease – is published in the journal Nature Communications.

CHAMPAIGN, Ill. — Tumors are notoriously difficult to study in their natural habitat – body tissues – but a new synthetic tissue environment may give cancer researchers the next-best look at tumor growth and behavior.

University of Illinois researchers say they now know how to track and map drug and gene delivery vehicles to evaluate which are most effective at infiltrating cells and getting to their targets, insight that could guide development of new pharmaceutical agents. The researchers described their tracking system and their findings on the most effective delivery vehicles in the journal Nature Communications. 

CHAMPAIGN, Ill. - One infrared scan can give pathologists a window into the structures and molecules inside tissues and cells, enabling fast and broad diagnostic assessments, thanks to an imaging technique developed by University of Illinois researchers and clinical partners.

CHAMPAIGN, Ill. — Eye doctors soon could use computing power to help them see individual cells in the back of a patient’s eye, thanks to imaging technology developed by engineers at the University of Illinois. Such detailed pictures of the cells, blood vessels and nerves at the back of the eye could enable earlier diagnosis and better treatment for degenerative eye and neurological diseases.

A new microscope system can image living tissue in real time and in molecular detail, without any chemicals or dyes, report researchers at the University of Illinois.

CHAMPAIGN, Ill. - The news a cancer patient most fears is that the disease has spread and become much more difficult to treat. A new method to isolate and grow the most dangerous cancer cells could enable new research into how cancer spreads and, ultimately, how to fight it.

A meta-analysis of dozens of studies of traditional Chinese medicine and other nonpharmacological interventions meant to improve patients’ quality of life affirms that these approaches, on the whole, help alleviate depression, fatigue, pain, anxiety, insomnia and gastrointestinal problems in Chinese cancer patients.

CHAMPAIGN, Ill. - With more new mothers in the workplace than ever before, there has been a corresponding increase in the number of child-care facilities in the United States.

After a primary tumor is treated, cancer stem cells may still lurk in the body, ready to metastasize and cause a recurrence of the cancer in a form that’s more aggressive and resistant to treatment. University of Illinois researchers have developed a molecular probe that seeks out these elusive cells and lights them up so they can be identified, tracked and studied not only in cell cultures, but in their native environment: the body.

In a paper published in the journal ACS Central Science, the researchers described the probe’s effectiveness in identifying cancer stem cells in cultures of multiple human cancer cell lines as well as in live mice.

CHAMPAIGN, lll. - Doctors can now get a peek behind the eardrum to better diagnose and treat chronic ear infections, thanks to a new medical imaging device invented by University of Illinois researchers. The device could usher in a new suite of non-invasive, 3-D diagnostic imaging tools for primary-care physicians.

A new study found that monounsaturated fatty acids are linked to general intelligence and the organization of the brain’s attention network.

Thin tissue grafts and flexible electronics have a host of applications for wound healing, regenerative medicine and biosensing. A new device inspired by an octopus’s sucker rapidly transfers delicate tissue or electronic sheets to the patient, overcoming a key barrier to clinical application, report researchers at the University of Illinois at Urbana-Champaign and collaborators.

CHAMPAIGN, Ill. — Wearing a fitness tracker on your wrist or clipped to your belt is so 2013. Engineers at the University of Illinois at Urbana-Champaign and Northwestern University have demonstrated thin, soft stick-on patches that stretch and move with the skin and incorporate commercial, off-the-shelf chip-based electronics for sophisticated wireless health monitoring.

A number of drugs already approved to treat parasitic infections, cancers, infertility and other conditions also show promise as antibiotic agents against staph and tuberculosis infections, according to a new study by University of Illinois chemists and collaborators.

CHAMPAIGN, lll. — Fitness DVDs are a multimillion-dollar business, and those targeting adults over the age of 55 are a major part of the market. With names like “Boomers on the Move,” “Stronger Seniors” and “Ageless Yoga,” the programs promise much, but few have ever been rigorously tested.

CHAMPAIGN, Ill. — A study of older adults at risk of late-onset Alzheimer’s disease found that those who consumed more omega-3 fatty acids did better than their peers on tests of cognitive flexibility – the ability to efficiently switch between tasks – and had a bigger anterior cingulate cortex, a brain region known to contribute to cognitive flexibility.

While many cancer survivors experience food insecurity, few oncology registered dietitians interviewed by U. of I. researchers indicated that they routinely screen their patients for it.

CHAMPAIGN, Ill. - Researchers report that one tiny variation in the sequence of a gene may cause some people to be more impaired by traumatic brain injury (TBI) than others with comparable wounds.