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  • New compounds block master regulator of cancer growth, metastasis

    Researchers including, from left, Valeria Sanabria Guillen, Jung Soon Hoon Kim, Kathy Carlson, John Katzenellenbogen, Yvonne Ziegler, and Benita Katzenellenbogen developed new drug agents to inhibit a pathway that contributes to cancer. The compounds killed cancer cells and reduced the growth of breast cancer tumors in mice.

    Researchers including, from left, graduate student Valeria Sanabria Guillen, research scientist Sung Hoon Kim, researcher Kathy Carlson, chemistry professor John Katzenellenbogen, research specialist Yvonne Ziegler, and molecular and integrative physiology professor Benita Katzenellenbogen developed new drug agents to inhibit a pathway that contributes to cancer. The compounds killed cancer cells and reduced the growth of breast cancer tumors in mice. 

    Photo by L. Brian Stauffer

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  • Editor’s notes:
    To reach Benita Katzenellenbogen, call 217-333-9769; email katzenel@illinois.edu.  
    To reach John Katzenellenbogen, call 217-333-6310; email jkatzene@illinois.edu.  

    The paper “Suppression of FOXM1 activities and breast cancer growth in vitro and in vivo by a new class of compounds” is available online and from the U. of I. News Bureau.

    DOI: 10.1038/s41523-019-0141-7