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  • Unmuting large silent genes lets bacteria produce new molecules, potential drug candidates

    Illinois researchers developed a technique to unmute silent genes in Streptomyces bacteria using decoy DNA fragments to lure away repressors. Pictured, from left: postdoctoral researcher Fang Guo, professor Huimin Zhao and postdoctoral researcher Bin Wang

    Illinois researchers developed a technique to unmute silent genes in Streptomyces bacteria using decoy DNA fragments to lure away repressors. Pictured, from left: postdoctoral researcher Fang Guo, professor Huimin Zhao and postdoctoral researcher Bin Wang.

    Photo by L. Brian Stauffer

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  • Editor’s notes: To reach Huimin Zhao, call (217) 333-2631; email: zhao5@illinois.edu.

    The paper “Activation of silent biosynthetic gene clusters using transcription factor decoys” is available online.

    DOI: 10.1038/s41589-018-0187-0