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  • Scientists discover how antibiotics penetrate Gram-negative bacterial cell walls

    Photo of research team.

    The research team, including, from left, Nandan Haloi, Archit Kumar Vasan, Emily Geddes and Emad Tajkhorshid, invented and tested a new method for determining how chemical compounds interact with proteins in cells. Their approach offers atomic-level insight into the chemical properties that allow some antibiotics to pass through pores in the cell membranes of Gram-negative bacteria.

     

    Photo by L. Brian Stauffer

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  • Editor’s notes

    To reach Emad Tajkhorshid, email emad@illinois.edu.

    To reach Paul Hergenrother, email hergenro@illinois.edu.

    To reach William Metcalf, email metcalf@illinois.edu.

    The paper “Rationalizing the generation of broad-spectrum antibiotics with the addition of a positive charge” is available online and from the U. of I. News Bureau.

    DOI: 10.1039/d1sc04445a