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  • Possible genetic basis and mouse model found for severe nonalcoholic fatty liver disease

    A graphic of a DNA shield guarding a simple human figure with the liver highlighted

    The SRSF1 gene acts as a guardian against DNA damage in the liver, University of Illinois Urbana-Champaign researchers found. When it is missing or inactivated, severe nonalcoholic fatty liver disease symptoms develop.

    Image by Michael Vincent


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  • Editor’s notes: To reach Auinash Kalsotra, email:

    The paper “Splicing factor SRSF1 deficiency in the liver triggers NASH-like pathology and cell death” is available online. DOI: 10.1038/s41467-023-35932-3


    The research team also included Illinois graduate students Bhoomika Mathur, Ullas Chembazhi, Sushant Bangru, Katelyn Toohill, You Jin Song and Qinyu Hao; cell and developmental biology professor Prasanth Kannanganattu and molecular and integrative physiology professor Sayeepriyadarshini Anakk; Michael Saikali and Carolyn Cummins of the University of Toronto; Saman Karimi and  Grace Guzman of the University of Illinois Hospital and Health Sciences System, Chicago; and Steven  Blue, Brian Yee, Eric Van Nostrand and Gene Yeo of the University of California, San Diego.