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  • CAR-T immune therapy attacks ovarian cancer in mice with a single dose

    The research team sits and stands together as a group in a research setting.

    A cross-disciplinary research team from the University of Illinois Urbana-Champaign demonstrated a CAR-T immune therapy effective at attacking late-stage ovarian cancer in mice with a single dose, providing evidence that CAR-T therapies could effectively treat solid-tumor cancers. Pictured, from front left: postdoctoral researcher Diana Rose Ranoa, graduate student Claire Schane, professor emeritus of biochemistry David Kranz (front center), researcher Amber Lewis and professor emeritus of pathology Edward Roy.

    Photo by Fred Zwicky


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  • Editor’s notes: To reach David Kranz, email To reach Diana Ranoa, email

    The paper “Single CAR-T cell treatment controls disseminated ovarian cancer in a syngeneic mouse model” is available online. DOI: 10.1136/jitc-2022-006509

    The National Institutes of Health supported this work under grants CA238628, CA120439, CA256746 and CA022677.