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  • CRISPR-Cas13 targets proteins causing ALS, Huntington's disease in the mouse nervous system

    A microscope image of cells

    Spinal cord astrocytes, the cells seen in this fluorescent microscope image, are involved in the progression of ALS. A new CRISPR-Cas13 system targeting mutant protein production in these cells improved outcomes for mice with ALS.

    Image courtesy of Thomas Gaj and Colin Lim


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  • Editor’s Note: To reach Thomas Gaj, email  

    The paper “Targeted gene silencing in the nervous system with CRISPR-Cas13” is available online.

    DOI: 10.1126/sciadv.abk2485