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  • Shape-shifting agent targets harmful bacteria in the stomach

    At normal tissue pH (left), the polymer does not kill bacteria. But in an acidic environment (right), it disrupts the H. pylori bacteria’s membranes to kill it.

    At normal tissue pH (left), the polymer is not active and does not kill bacteria. But in an acidic environment (right), it disrupts the H. pylori bacteria’s membranes to kill it.

    Images courtesy of Jianjun Cheng.

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  • Editor’s notes: To contact Jianjun Cheng, call 217-244-3924 ; email: jianjunc@illinois.edu. To contact Lin-Feng Chen, call 217-333-7764; email: lfchen@life.illinois.edu.

    The paper “Selective killing of Helicobacter pylori with pH-responsive helix-coil conformation transitionable antimicrobial polypeptides” is available online or from the News Bureau. DOI:10.1073/pnas.1710408114