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  • CRISPR mines bacterial genome for hidden pharmaceutical treasure

    Illinois researchers used CRISPR technology to activate silent gene clusters in Streptomyces bacteria, a potential treasure trove of new classes of drugs. Pictured, clockwise from back middle: graduate student Behnam Enghiad, postdoctoral researcher Shangwen Luo, graduate student Tajie Luo and professor Huimin Zhao.

    Illinois researchers used CRISPR technology to activate silent gene clusters in Streptomyces bacteria, a potential treasure trove of new classes of drugs. Pictured, clockwise from back middle: graduate student Behnam Enghiad, postdoctoral researcher Shangwen Luo, graduate student Yajie Wang and professor Huimin Zhao.

    Photo by L. Brian Stauffer

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  • To reach Huimin Zhao, call (217)333-2631; email: zhao5@illinois.edu.

    The paper “CRISPR–Cas9 strategy for activation of silent Streptomyces biosynthetic gene clusters” is available online. doi:10.1038/nchembio.2341