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  • Potential new cystic fibrosis treatment uses 'molecular prosthetic' for missing lung protein

    People with cystic fibrosis are missing a protein in the lining of the lung that releases bicarbonate, a key infection-fighting agent. The drug amphotericin can form channels to release bicarbonate in lung tissue, restoring the airway surface liquid’s antibiotic properties.

    People with cystic fibrosis are missing a protein in the lining of the lung that releases bicarbonate, a key infection-fighting agent. The drug amphotericin can form channels to release bicarbonate in lung tissue, restoring the airway surface liquid’s antibiotic properties.

    Graphic by Rebecca Schultz

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  • Editor’s notes:

    To reach Martin Burke, call 217-244-8726; email: mdburke@illinois.edu.  

    To reach Michael Welsh, email michael-welsh@uiowa.edu.

    The paper “Small molecule ion channels increase host defenses in cystic fibrosis airway epithelia” is available online or from the News Bureau.

    A downloadable multimedia gallery is availabe at https://uofi.box.com/v/burkecf.