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  • New antifungal molecule kills fungi without toxicity in human cells, mice

    An artists rendering of an amphotericin B sterol sponge

    The mechanism for a critical but highly toxic antifungal is revealed in high resolution. Self-assembled Amphotericin B sponges (depicted in light blue) rapidly extract sterols (depicted in orange and white) from cells. This atomic level understanding yielded a novel kidney-sparing antifungal agent.

    Image by Jose Vazquez


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  • Editor’s notes: To reach Martin Burke, email:  

    The paper “Tuning sterol extraction kinetics yields a renal sparing polyene antifungal” is available online. DOI: 10.1038/s41586-023-06710-4
    The National Institutes of Health supported this work under grants 5R01-AI135812-04, R35-GM118185, R01-GM112845 and R01-GM123455, R01-AI063503 and P41-GM136463.

    Competing interests: A.M., J. Z., S.Y., C.M.R. and M.D.B are inventors on patents PCT/US20/45566, PCT/US20/45399, PCT/US 2021/45205, PCT/US2020/45387 and/or UIUC2022-022-01, submitted by the U. of I. 
     M.D.B and K.A.M disclose consulting income and equity in Sfunga Therapeutics.