News Bureau

CAR-T immune therapies could be effective against solid tumors if the right targets are identified, a new study led by University of Illinois Urbana-Champaign researchers suggests. The researchers successfully deployed CAR-T in a mouse model of ovarian cancer, a type of aggressive, solid-tumor cancer that has eluded such therapies until now.

Scientists have identified a protein that plays a critical role in the action of several emerging cancer therapies. The researchers say the discovery will likely aid efforts to fine-tune the use of immunotherapies against several challenging cancers. They report their findings in the journal Cancer Research.

In an advance that will help scientists track coronavirus variants in wild and domesticated animals, researchers report they can now detect exposure to the SARS-CoV-2 virus in any animal species. Most coronavirus antibody tests require specialized chemical reagents to detect host antibody responses against the virus in each species tested, impeding research across species.

Cancer surgeons may soon have a more complete view of tumors during surgery thanks to new imaging agents that can illuminate multiple biomarkers at once, University of Illinois Urbana-Champaign researchers report. The fluorescent nanoparticles, wrapped in the membranes of red blood cells, target tumors better than current clinically approved dyes and can emit two distinct signals in response to just one beam of surgical light, a feature that could help doctors distinguish tumor borders and identify metastatic cancers.

“The New Normal,” a 30-minute documentary premiering May 23 at 1:30 p.m. CST/ 2:30 p.m. EST on the Big Ten Network, documents the journey of University of Illinois Urbana Champaign researchers to create a fast and inexpensive coronavirus test to ensure that U. of I. students, faculty and staff could remain safe and healthy during the pandemic

Newly developed “smart” coatings for surgical orthopedic implants can monitor strain on the devices to provide early warning of implant failures while killing infection-causing bacteria, University of Illinois Urbana-Champaign researchers report. The coatings integrate flexible sensors with a nanostructured antibacterial surface inspired by the wings of dragonflies and cicadas.

A new study found that blood markers of two saturated fatty acids along with certain omega-6, -7 and -9 fatty acids correlated with better scores on tests of memory and with larger brain structures in the frontal, temporal, parietal and insular cortices.

Illinois Ph.D. candidate Sulagna Chakraborty describes awareness of ticks and tick-borne disease among Illinois farmers.

A new artificial intelligence tool can predict the functions of enzymes based on their amino acid sequences, even when the enzymes are unstudied or poorly understood. The researchers said the AI tool, dubbed CLEAN, outperforms the leading state-of-the-art tools in accuracy, reliability and sensitivity. Better understanding of enzymes and their functions would be a boon for research in genomics, chemistry, industrial materials, medicine, pharmaceuticals and more.

A new study is the first to compare the sound exposures of fetuses in the last 16 weeks of pregnancy with their age-matched premature peers. The analysis reveals profound differences in their exposures to noise, language and the biological sounds of the mother, with implications for the infants’ development.

A new book from University of Illinois Urbana-Champaign anthropology professor Kathryn Clancy takes an unflinching look at the many ways humans have struggled – and often failed – to understand one of the greatest mysteries of human biology: menstruation.

Sociology professor Kevin Leicht is co-leading the development of a software app that will alert clinicians to medical misinformation that's circulating on social media so they can address it with their patients if desired.

Black and Latina women had high rates of anxiety and depressive symptoms during the pandemic, but prayer had differing effects, kinesiology and community health professor Sandraluz Lara-Cinisomo found in a study.

The U.S. methamphetamine mortality rate increased fiftyfold between 1999 and 2021, with most of the added deaths also involving heroin or fentanyl, researchers report in the American Journal of Public Health.

A mutant or damaged gene may be a cause of a severe, mysterious form of nonalcoholic fatty liver disease, University of Illinois Urbana-Champaign researchers have found. Mice and human liver cells lacking the SRSF1 gene show all the hallmarks of nonalcoholic steatohepatitis, also known as NASH, the researchers found. The unique mouse model captures all three hallmarks of excess fat, inflammation and scarring in the liver, opening the doors to better understanding and development of treatments for NASH.

Adolescent girls who engage in more moderate and vigorous physical activity each day have better attentional control, a new study finds. The study focused on girls and boys aged 15-18.

Scientists have developed a tiny mechanical probe that can measure the inherent stiffness of cells and tissues as well as the internal forces the cells generate and exert on one another. Their new “magnetic microrobot” is the first such probe to be able to quantify both properties, the researchers report, and will aid in understanding cellular processes associated with development and disease.

A new paper co-written by University of Illinois Urbana-Champaign legal scholar Jacob S. Sherkow argues that the state of California’s proposal to manufacture and distribute insulin at cost could be a game-changer for curbing out-of-control price increases and a boon to public health.

Soybean varieties with greater proportions of the protein B-conglycinin reduce plasma cholesterol levels and promote liver homeostasis, showing potential for preventing fatty liver disease and atherosclerosis, according to research by food scientists at the University of Illinois Urbana-Champaign.

A strong commitment to their ethnic identity may be a double-edged sword for young sexual minority Black men when they encounter sexual racism online, according to a study by U. of I. social work professor Ryan Wade.

A phase I clinical trial of PAC-1, a drug that spurs programmed cell death in cancer cells, found only minor side effects in patients with end-stage cancers. The drug stalled the growth of tumors in the five people in the trial with neuroendocrine cancers and reduced tumor size in two of those patients. It also showed some therapeutic activity against sarcomas, scientists and clinicians report in the British Journal of Cancer.

Thomas O’Rourke, a professor emeritus of kinesiology and community health at the University of Illinois Urbana-Champaign, spoke with News Bureau life sciences editor Diana Yates about how previous efforts to institute public health measures succeeded and how the same approaches can be employed to reduce the scourge of gun violence in the U.S.

Scientists have labored for decades to understand how brain structure and functional connectivity drive intelligence. A new analysis offers the clearest picture yet of how various brain regions and neural networks contribute to a person’s problem-solving ability in a variety of contexts, a trait known as general intelligence, researchers report.

Communication professor Charee Thompson studied implicit bias in health care and women’s prolonged struggles to obtain treatment and emotional support for a variety of mental and physical health problems.

Less than 20% of diagnosed breast cancers are designated “triple-negative,” meaning that the affected tissues lack three types of receptors often found in other breast cancer types, but TNBCs are often aggressive with a higher risk of recurrence, metastasis and mortality. In a study conducted in TNBC cells and in a mouse model of the disease, researchers found that targeting a specific estrogen receptor that is sometimes present in TNBCs alters the activity of dozens of cancer-related genes and slows the growth and metastasis of these breast cancers.

While all of the “Big Five” personality traits – agreeableness, conscientiousness, extraversion, neuroticism and openness – are related to experiencing stress, neuroticism showed the strongest link, according to research co-written by Bo Zhang, a professor of labor and employment relations and of psychology at Illinois.

Diagnoses of suicidal ideation and depression increased dramatically among pregnant Black women from 2008-2018, according to a study led by University of Illinois social work professor Karen Tabb Dina.

The first two years of the COVID-19 pandemic saw an increase in mortality rates, both from COVID-19 and other causes, but the groups hardest hit shifted between the first and second years, according to an analysis of publicly available data. Both years saw an increase in deaths over the five years preceding the pandemic, even with COVID-19 numbers removed. But while the first year was most deadly for those over age 65, the second year hit middle-aged adults the hardest, University of Illinois Urbana-Champaign researchers found.

A study by a University of Illinois Urbana-Champaign team explored the impact of health care providers’ COVID-19 mitigation policies on women of color who were pregnant or gave birth during the pandemic.

Studies led by social work professor Moses Okumu found that teens in Uganda who "sexted" were more likely to use condoms and that the online media they use may be means of providing sexual health interventions.

Artificial intelligence, building-block chemistry and a molecule-making machine teamed up to find the best general reaction conditions for synthesizing chemicals important to biomedical and materials research – a finding that could speed innovation and drug discovery as well as make complex chemistry automated and accessible.

Researchers at the University of Illinois Urbana-Champaign and collaborators in Poland and Canada reported their findings in the journal Science.

University of Illinois Urbana-Champaign chemistry professor Dr. Martin D. Burke has been elected to the National Academy of Medicine for his work in chemical synthesis, molecular prosthetics and COVID-19 testing.

People who viewed sex as a leisure activity used their pandemic downtime to engage in more  frequent, creative and satisfying sex, U. of I. professor Liza Berdychevsky found in a recent survey. 

In an effort to streamline the process of diagnosing patients with multiple sclerosis and Parkinson’s disease, researchers used digital cameras to capture changes in gait – a symptom of these diseases – and developed a machine-learning algorithm that can differentiate those with MS and PD from people without those neurological conditions.

A new study found that 24-month-old children who spent less than 60 minutes looking at screens each day and those who engaged in daily physical activity had better executive function than their peers. Executive function includes the ability to remember, plan, pay attention, shift between tasks and regulate one's thoughts and behavior.

Tiny nets woven from DNA strands can ensnare the spike protein of the virus that causes COVID-19, lighting up the virus for a fast-yet-sensitive diagnostic test – and also impeding the virus from infecting cells, opening a new possible route to antiviral treatment, according to a new study led by the University of Illinois Urbana-Champaign.

New COVID-19 vaccine boosters that target omicron variants are being distributed. Although the variants seem less deadly, the boosters are needed to keep up with the virus as it evolves, says University of Illinois Urbana-Champaign microbiology professor Christopher Brooke, a virologist and vaccine expert.

Light-activated proteins can help normalize dysfunction within cells and could be used as a treatment for diseases such as cancer or mitochondrial diseases, new research suggests.

Researchers from the University of Cincinnati, the University of Illinois Urbana-Champaign and the University at Buffalo published the results of their study in the journal Nature Communications. The research centers on the functions of mitochondria, organelles within a cell that act as the cell’s “power plant” and source of energy.

Patients with squamous cell carcinoma of the head or neck were 93% less likely to die during the first three years after diagnosis if they ate a healthy diet high in nutrients found to deter chronic disease, U. of I. researchers found in a recent study.

A new analysis of reports from more than 35,000 people offers the most comprehensive assessment so far of menstrual changes experienced by pre- and post-menopausal individuals in the first two weeks after receiving the COVID-19 vaccine. Published in the journal Science Advances, the study adds to the evidence that significant numbers of people experience this unexpected side effect.

An individualized diet plan developed by nutritionists at the U. of I. shows promise at helping users lose weight and keep it off. The program uses a visual tool that encourages dieters to select foods high in protein and fiber.

Having high levels of compassion satisfaction buffered some temporary medical workers at a New York field hospital from stress disorders during the early days of the pandemic, a new study found.

A study of a herpes virus that infects chickens offers new insights into potentially problematic interactions between vaccines made from live viruses and the viruses they are meant to thwart.

When the coronavirus causing COVID-19 infects human cells, the cell’s protein-processing machinery makes modifications to the spike protein that render it more flexible and mobile, which could increase its ability to infect other cells and to evade antibodies, a new study from the University of Illinois Urbana-Champaign found.

The researchers created an atomic-level computational model of the spike protein and ran multiple simulations to examine the protein’s dynamics and how the cell’s modifications affected those dynamics. This is the first study to present such a detailed picture of the protein that plays a key role in COVID-19 infection and immunity, the researchers said.

A natural small molecule derived from a cypress tree can transport iron in live mice and human cells lacking the protein that normally does the job, easing a buildup of iron in the liver and restoring hemoglobin and red blood cell production, a new study found.

Latin dance lessons may boost the working memory of Latino older adults and help prevent age-related cognitive decline, says new research by kinesiology and community health professor Susan Aguiñaga.

In the fall of 2020, the University of Illinois Urbana-Champaign welcomed students back for in-person instruction amid the powerful first wave of the COVID-19 pandemic. The university successfully maintained operations throughout the semester – with zero COVID-19-related deaths or hospitalizations in the campus community – thanks to its “SHIELD: Target, Test, Tell” program. In a sweeping report, the team behind the campuswide collaboration details the innovations in modeling, saliva testing and results reporting that helped mitigate the spread of the virus, and shares the data collected and lessons learned through the process.

A team led by scientists at the University of Illinois Urbana-Champaign tracked the rise and fall of SARS-CoV-2 in the saliva and nasal cavities of people newly infected with the virus. The study was the first to follow acute COVID-19 infections over time through repeated sampling and to compare results from different testing methodologies.

A new study shows that it is possible to use the genetic sequences of a person’s antibodies to predict what pathogens those antibodies will target. Reported in the journal Immunity, the new approach successfully differentiates between antibodies against influenza and those attacking SARS-CoV-2, the virus that causes COVID-19.

A point-of-care COVID-19 test developed by researchers at the University of Illinois Urbana-Champaign can now detect and differentiate the alpha variant of the SARS-CoV-2 virus from earlier strains in saliva samples.