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High-volume antibody testing platform could accelerate disease research and treatment development
CHAMPAIGN, Ill. — Antibodies are the critical targeting agents of the immune system and the crux of immune therapy and vaccine development, but studying them is slow, expensive and labor-intensive. Now, researchers at the University of Illinois Urbana-Champaign have developed a new high-volume method that can rapidly build and test large numbers of antibodies at […]
Kidney fibrosis linked to molecule made by gut bacteria
A molecule made by bacteria in the gut can hitch a ride to the kidneys, where it sets off a chain reaction of inflammation, scarring and fibrosis — a serious complication of diabetes and a leading cause of kidney failure — according to a new study from researchers at the University of Illinois Urbana-Champaign and Mie University in Japan. The group also developed a new antibody that could counter it.
Illinois team updates state threatened, endangered plant species rankings
CHAMPAIGN, Ill. — Scientists from the Illinois Natural History Survey and the Illinois Department of Natural Resources have updated the state conservation status ranks, or S-ranks, of threatened and endangered plants in Illinois. The update includes some plants not recorded in the state for decades and finds many that, while still threatened, are doing better […]
Study identifies gene clusters in rhizobia linked to robust legume growth
CHAMPAIGN, Ill. — In a new study, scientists used nearly every tool in their toolkit — genomics, transcriptomics, greenhouse experiments and advanced statistical methods — to gain new insight into the complex chemical interactions that take place in underground root nodules, where legumes like soybeans exchange vital nutrients with soil microbes called rhizobia. Reported in […]
Map-making neurons change even in familiar settings, study finds
CHAMPAIGN, Ill. — Neurobiologists at Northwestern University and the University of Illinois Urbana-Champaign found the brain’s internal GPS changes each time mice navigate a familiar, static environment. Even when a mouse walks the same path every day — and the path and surrounding conditions remain identical — each journey activates different “map-making” neurons in the […]
Beyond the mammogram: Study finds differences between benign and cancerous breast calcifications
CHAMPAIGN, Ill. — Benign and cancerous calcium phosphate deposits that may look identical on a mammogram have distinct differences in their structures and formation processes, researchers at the University of Illinois Urbana-Champaign and collaborators at the Mayo Clinic and the University of Texas at Austin found in a new study that provides the first detailed […]
Flightpath Biosciences licenses microbiome-sparing antibiotic developed at Illinois
CHAMPAIGN, Ill. — Flightpath Biosciences, Inc., a clinical stage biotechnology company focused on the development of precision therapeutics targeting bacterial pathogens, has licensed a class of antibiotics developed at the University of Illinois Urbana-Champaign. The original antibiotic agent, lolamicin, effectively treated bacterial infections in animal models of disease — without wiping out beneficial microbes in […]
How are veterinarians advancing cancer research in dogs, people?
CHAMPAIGN, Ill. — People are beginning to realize that dogs share a lot more with humans than just their homes and habits. Some spontaneously occurring cancers in dogs are genetically very similar to those in people and respond to treatment in similar ways. This means inventive new treatments in dogs, when effective, may also be […]
Study links influenza A viral infection to microbiome, brain gene expression changes
CHAMPAIGN, Ill. — In a study of newborn piglets, infection with influenza A was associated with disruptions in the piglets’ nasal and gut microbiomes and with potentially detrimental changes in gene activity in the hippocampus, a brain structure that plays a central role in learning and memory. Maternal vaccination against the virus during pregnancy appeared […]
Machine-learning model reliably predicts cognitive performance
CHAMPAIGN, Ill. — A new study offers insight into the health and lifestyle indicators — including diet, physical activity and weight — that align most closely with healthy brain function across the lifespan. The study used machine learning to determine which variables best predicted a person’s ability to quickly complete a task without becoming distracted. […]
Eating craved foods with meals lessens cravings, boosts weight loss
CHAMPAIGN, Ill. — Food cravings are the downfall of many dieters, who feel locked in an eternal battle with their willpower to resist the tempting sweets, snacks and other foods they love. However, researchers in food science and human nutrition at the University of Illinois Urbana-Champaign say in a new study that eating dessert may […]
Review: Social drinking also a well-worn path to alcohol use disorder
CHAMPAIGN, Ill. — When picturing a “typical” alcoholic, people tend to imagine a person drinking at home alone. But that focus overlooks the social origins of many serious alcohol problems, say the authors of a new review paper in the journal Current Directions in Psychological Science. “Evidence for the centrality of social motives in problem […]