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  • Nanoneedle is small in size, but huge in applications

    From left, Yang Xiang, professor of molecular and integrative physiology; Min-Feng Yu and Ning Wang, both professors of mechanical science and engineering, have developed a membrane-penetrating nanoneedle for the targeted delivery of one or more molecules into the cytoplasm or the nucleus of living cells.

    From left, Yang Xiang, professor of molecular and integrative physiology; Min-Feng Yu and Ning Wang, both professors of mechanical science and engineering, have developed a membrane-penetrating nanoneedle for the targeted delivery of one or more molecules into the cytoplasm or the nucleus of living cells.

    Photo by L. Brian Stauffer

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      From left, Yang Xiang, professor of molecular and integrative physiology; Min-Feng Yu and Ning Wang, both professors of mechanical science and engineering, have developed a membrane-penetrating nanoneedle for the targeted delivery of one or more molecules into the cytoplasm or the nucleus of living cells.

      Photo by L. Brian Stauffer

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      Schematic illustrating the strategy of the nanoneedle-based delivery of bioprobes into the cell, along with the combined fluorescence and bright-field images showing the nanoneedle penetrating through the cell membrane, and the quantum dots (in red) target-delivered into the cytoplasm and the nucleus of a living cell.

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