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  • Computational microscope peers into the working ribosome

    Physics professor Klaus Schulten and graduate student Leonardo Trabuco, left, and postdoctoral researcher James Gumbart, with model of a ribosome, are using the computer as a microscope to decipher the chemical details of ribosome function.

    Physics professor Klaus Schulten and graduate student Leonardo Trabuco, left, and postdoctoral researcher James Gumbart, with model of a ribosome, are using the computer as a microscope to decipher the chemical details of ribosome function.

    Photo by L. Brian Stauffer

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  • Editor's note: To To reach Klaus Schulten call 217- 244-1604; e-mail schulten@illinois.edu.
    The published papers are available at the following links:
    Ribosome-induced changes in elongation factor Tu conformation control GTP hydrolysis. Elizabeth Villa, Jayati Sengupta, Leonardo G. Trabuco, Jamie LeBarron, William T. Baxter, Tanvir R. Shaikh, Robert A. Grassucci, Poul Nissen, Måns Ehrenberg, Klaus Schulten, and Joachim Frank. Proceedings of the National Academy of Sciences, USA, 106: 1063-1068, 2009.
    Regulation of the protein-conducting channel by a bound ribosome. James Gumbart, Leonardo G. Trabuco, Eduard Schreiner, Elizabeth Villa, and Klaus Schulten. Structure, 17: 1453-1464, 2009.

    More information on Molecular Dynamics Flexible Fitting