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  • Cancer-associated long non-coding RNA regulates pre-mRNA splicing

    Cell and developmental biology professor Kannanganattu Prasanth, left, postdoctoral researcher Vidisha Tripathi, seated, undergraduate research assistant David Song and their colleagues found that a long non-coding RNA, MALAT1, plays a key role in pre-mRNA processing. Aberrant regulation of the MALAT1 gene is associated with several cancers, as are some of the splicing factors it regulates. Similarly, some of the genes whose pre-mRNA splicing is regulated by MALAT1 are cancer "signature genes."

    Cell and developmental biology professor Kannanganattu Prasanth, left, postdoctoral researcher Vidisha Tripathi, seated, undergraduate research assistant David Song and their colleagues found that a long non-coding RNA, MALAT1, plays a key role in pre-mRNA processing. Aberrant regulation of the MALAT1 gene is associated with several cancers, as are some of the splicing factors it regulates. Similarly, some of the genes whose pre-mRNA splicing is regulated by MALAT1 are cancer "signature genes."

    Photo by L. Brian Stauffer

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      Cell and developmental biology professor Kannanganattu Prasanth, left, postdoctoral researcher Vidisha Tripathi, seated, undergraduate research assistant David Song and their colleagues found that a long non-coding RNA, MALAT1, plays a key role in pre-mRNA processing. Aberrant regulation of the MALAT1 gene is associated with several cancers, as are some of the splicing factors it regulates. Similarly, some of the genes whose pre-mRNA splicing is regulated by MALAT1 are cancer "signature genes."

      Photo by L. Brian Stauffer

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