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  • Chemists document workings of key staph enzyme - and how to block it

    Chemists led by Illinois professor Eric Oldfield, center, determined the structure of a key enzyme that could lead to more efficient drugs to treat staph infections, parasites and high cholesterol. The research team, from left, research scientist Yonghui Zhang, graduate student Fu-Yang Lin, research scientist Rong Cao and postdoctoral associate Ke Wang.

    Chemists led by Illinois professor Eric Oldfield, center, determined the structure of a key enzyme that could lead to more efficient drugs to treat staph infections, parasites and high cholesterol. The research team, from left, research scientist Yonghui Zhang, graduate student Fu-Yang Lin, research scientist Rong Cao and postdoctoral associate Ke Wang.

    Photo by L. Brian Stauffer

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  • Editor's note: To contact Eric Oldfield, call 217-333-3374; e-mail eo@chad.scs.uiuc.edu.
    The paper, “Mechanism of Action and Inhibition of Dehydrosqualene Synthase,” is available online.