Fiber-boosted formula for piglets shows promise in battle against infant diarrhea
Jim Barlow, Life
Sciences Editor
(217) 333-5802; jebarlow@illinois.edu
6/2/03
CHAMPAIGN, Ill. — Adding
fiber to the diet for bowel health is standard advice for adults. Such wisdom
also may benefit babies, say researchers who are testing the impact of fiber
added to milk-replacement formulas of newborn piglets.
In the June issue of the
Journal of Nutrition, the researchers reported that piglets that consumed formula
with moderate levels of fermentable fiber tolerated an induced infection of
Salmonella typhimurium much better than those fed a plain control formula or
one with a non-fermentable fiber.
The ongoing research at the University of Illinois at Urbana-Champaign is targeting
a $2 billion-a-year, sometimes fatal problem – acute diarrhea –
that, according to the Centers for Disease Control and Prevention, accounts
for about 9 percent of all hospitalizations of children under age 5 in the United
States annually. While experts encourage mothers to breast feed their infants
to stimulate natural protection against a multitude of diseases, the vast majority
of infants are fed infant formulas.
"We know that breast milk is important because it sets up microbiota in
the colon and fights off infections," said Kelly Tappenden, professor of
food science and human nutrition and principal investigator of the research.
"Infants are most susceptible to diarrhea diseases compared to other segments
of the population. Many such diseases peak in the first year of life. We are
interested in trying to prevent diarrhea-related diseases in babies. Our hope
is that infant formulas can be enhanced to provide much of the same activity
that a mother’s milk will do."
Tappenden and colleagues divided 48 two-day-old piglets into four groups fed
in equal amounts every 12 hours. The gastrointestinal tract and general development
of neonatal piglets are similar to that of human infants born about eight weeks
early.
The more rapid growth rate of the piglets allows researchers to observe changes
at a rapid pace.
A control group received a standard sow-milk replacement formula. A second group
got formula supplemented with non-fermentable fiber (methylcellusose). The other
two groups, respectively, received formulas containing soy polysaccharide (a
moderately fermentable fiber) and fructo-oligosaccharides (a highly fermentable
fiber).
The fiber sources are among multiple possibilities and were chosen to test a
broad range of levels, Tappenden said. The soy fiber is different than the soy
protein that is used in soy-based formulas for babies that are allergic to cow’s
milk.
After seven days, the piglets were infected with the salmonella strain that
commonly occurs in infants. The piglets’ activity and signs of illness
were monitored for seven more days, after which the piglets’ small intestines
and colons were evaluated.
"There was no change in body temperature among the piglets, but there was
a reduced incidence of diarrhea, and the activity level was maintained for those
on the higher fiber diets," Tappenden said. "The control animals and
those that were fed the non-fermentable fiber developed severe diarrhea and
became very lethargic. What that tells us is that it is not just fiber that
is important, but fiber quality is very important and that we need a fermentable
fiber."
In the experimental piglets, there were positive changes in the transport of
nutrients. However, Tappenden said that her team might have waited too long
into the recovery process to do the analysis, preventing an accurate determination
of what the changes were and why they occurred.
"So now we are looking at the first 48 hours after infection," she
said. "We know that fermentable fiber is doing something positive, but
we still cannot say why. These new tests may help us answer that by looking
at the conditions at the peak of infection."
Fibers are fermented in the body into short-chain fatty acids, which are short
lipid molecules that are thought to be good for the digestive tract, providing
increased intestinal structure and function, as well as promoting resistance
against invading pathogens.
These pre-clinical results are encouraging but far from leading to changes in
infant formulas, Tappenden said. "By our results, we could see that adding
dietary fiber does not seem to alter the development of a newborn’s intestinal
tract," she said. "It made no difference to the healthy group. The
presence of the fiber did help in an infectious state, however. Thus it may
be that all newborns could consume the fiber without the worry of negative consequences
on their development."
The Illinois Council on Food and Agricultural Research funded the project.
Authors of the study were Tappenden; Nancy J. Correa-Matos, a doctoral student
in the department of food science and human nutrition; Sharon M. Donovan, holder
of the Melissa M. Noel Chair in Nutrition and Health in the College of Agricultural,
Consumer and Environmental Sciences and professor of pediatrics in the College
of Medicine at Urbana-Champaign; Richard Isaacson, professor in the department
of veterinary pathobiology in the College of Veterinary Medicine; and H. Rex.
Gaskins and Bryan A. White, professors in the departments of animal sciences
and veterinary pathobiology.